Isotretinoin
Alias: Accutane
CAS No.: 4759-48-2
MF: C20h28o2
MW: 300.44
EINECS: 225-296-0
Assay: 99%
Appearance: Orange Crystal Powder
Specification: USP
HS Code: 2936210000
Minimum Package: 50g
Origin: China
Melting point: 172-175 ° C
Storage conditions: -20 ° C
Water solubility: insoluble
Stability:Stable, but probably air and light sensitive. Incompatible with strong oxidizing agents
Uses: For the treatment of severe acne embolism

Isotretinoin, (also known as 13-cis retinoic acid), trade names are ,Claravis, Decutan, Isotane, Sotret, Oratane, Izotek, Amnesteem, and Isotroin, is a medication primarily used to treat cystic acne. Anabolic steroids, which are commonly consumed by athletes and bodybuilders to create muscle mass, can also cause acne in men. Isotretinoin is an isomer of Vitamin A (13-cis-Vitamin A acid) which reduces the amount of oil released by sebaceous/oil glands in skin. It is used to treat moderate to severe acne, and to help skin more rapidly renew itself.

Specification

Items Specification results
Description Yellow crystalline powder Orange red crystal
Identifications Complies Complies
Organic Volatile Impurity Complies Complies
Loss on drying ≤0.5% 0.18
residue on ignition ≤0.1% 0.05%
Heavy Metals <0.002% <0.002%
Limit of Tretinoin ≤0.1% 0.18%
Assay 98.0~~102.0% 99.4%

Application
Isotretinoin is used to treat severe cystic acne (also known as nodular acne) that has not responded to other treatment (e.g., benzoyl peroxide or clindamycin applied to the skin or tetracycline or minocycline taken by mouth).
Isotretinoin is primarily used as a treatment for severe acne. The most common adverse effects are a transient worsening of acne (lasting 2-3 weeks), dry lips (cheilitis), dry and fragile skin, and an increased susceptibility to sunburn.
As the retinoid, there are strong and fast proliferation inhibition and differentiation of skin gland cell function, effective on severe nodular cystic acne. The gastrointestinal absorption is better, while the local medication invalid. Other drugs used to treat invalid serious acne, cystic acne, acne conglobata, rosacea, ichthyosis, keratosis follicularis and pityriasis rubra pilaris and other skin diseases also have a certain effect.
For severe acne. Anti skin dyskeratosis medicine. For the treatment of severe acne and other disorders

Usage of Isotretinoin 

1. Medical applications: the lack of nutrition of the elderly, thin, for severe burns and had the operation people.
2. Sports purpose: promote muscle growth, increased training and endurance training load, it has never been proved.
3. Adaption: Trauma, chronic infection, malnutrition and wasting disease and All kinds of refractory anemia.

—Landmark Elite Team

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